Peripheral muscle relaxant short-acting. Interacting with the n-cholinergic receptors, it causes depolarization of the endplate of the synapse, which comes into force on neuromuscular transmission blockade.At the beginning of the process of muscle relaxation may cause muscle fasciculations (the result of short-term relief of neuromuscular transmission). Muscle relaxation occurs in the following sequence: the eyelids, chewing muscles, muscles of the extremities, the abdominal muscles, the muscles of the vocal cords anadroll and diaphragm. Depolarization process is not terminated under the influence of cholinesterase inhibitors (eg, neostigmine).
From a long-acting muscle relaxants  has a rapid and short-acting. When intravenously effect develops within 30-60 seconds and lasts for 2-6 minutes. In intramuscular effect starts after 75 seconds – 3 minutes in adults and 3.5 minutes in children and lasts 30 minutes for adults and 21 minutes for children. This allows to achieve the required degree of muscle relaxation during such operations, when a long relaxation of the striated muscle is required.
In rare cases, may show prolonged muscle relaxant action if (dosage 3-5 mg / kg body weight) administered fractionally long (double blocking). In this phase, the action  can be neutralized by neostigmine.

after intravenous distributed in plasma and extracellular fluid. More than 90% hydrolyzed to serum cholinesterase and choline suktsinilmonoholina. do not possess pharmacological activity. The half-life of 90 seconds with normal cholinesterase. Excreted by the kidneys (10% unchanged). It does not cross the intact blood-brain barrier. Not accumulates.

States that require short-term relaxation of skeletal muscles, including endotracheal intubation prior to surgery, reduction of dislocation, repositioning of displaced fractures, the prevention of spontaneous damage during electroshock therapy.

Hypersensitivity to suxamethonium chloride, expressed human liver, pulmonary edema, severe hyperthermia, malignant hyperthermia (in history), reduced levels of cholinesterase in plasma, hyperkalemia or hyperkalemia risk after multiple injuries (5-90 days), severe burns, penetrating eye injury , a disease with impaired neuromuscular transmission, children under 1 year, patients with uremia, especially at high levels of serum potassium. Pregnancy and lactation. Precautions: Patients with heart disease, children from 1 year (see specific instructions.), Narrow-angle glaucoma.

Dosage and administration
intravenously or as an infusion, intramuscular injection. For continuous drip infusion using 0.1% solution . The dosage depends on the desired degree of muscle relaxation, body weight and sensitivity of the individual patient.
When administered  is observed relaxation of skeletal muscle function without respiratory depression. A dose of 0.2 mg / kg to 1.0 mg / kg results in a complete relaxation of the muscles of the abdominal wall and skeletal muscle and, further, to limit or stop spontaneous respiration. If intravenous administration is not possible, it is assigned to the 2.5 mg / kg body weight intramuscularly maximum 150mg. Start of muscle relaxation may be slightly delayed when administered intramuscularly.
Kids used only when absolutely necessary (see. Special instructions). The dosage for children is 1-2 mg / kg body weight intravenously, or 2.5 mg / kg -vnutrimyshechno.
Intravenous drip: depending on the patient’s weight and the desired degree of muscle relaxation dose for adults is 0.5 mg – 5 mg / min in a 0.1-0.2% solution.
anadroll compatible with isotonic sodium chloride solution, Ringer’s solution, dextrose 5% and 6% dextran.

The vials with a fault line Sawing is not required Position ampoules hand colored dot on top! Shake the vial to remove the solution from the tip of the ampoule.

Color point above! The tip of the ampoule to break off downwards.

Side effects:
tachycardia or bradycardia, arrhythmia, ventricular fibrillation, decrease or increase in blood pressure, increased intraocular pressure, bronchial spasm or throat, excessive salivation, myoglobinuria. muscle rigidity, postoperative muscle pain malignant hyperthermia, increased intracranial pressure, and intragastric, “dual” unit.
The reasons for the increase muscle relaxation time, including sleep apnea may be deficient in serum cholinesterase (including hereditary).

Symptoms: increased severity of side effects, respiratory arrest. Treatment: transfusions of whole blood or plasma canned, artificial respiration with intermittent positive pressure. Translation in a “double locking” followed by the application of neostigmine.

Interaction with other drugs Pharmaceutical: Mixing  with drugs that have an alkaline reaction medium, (eg, barbiturates) may lead to a lack . Pharmacodynamic and pharmacokinetic: Pretreatmentenhances the action of non-depolarizing relaxants. Pre-appointment of non-depolarizing relaxants reduces or prevents side reactions. Adverse reactions associated with blood circulation, strengthened when taking halogenated narcotic drugs (halothane), weakened while taking thiopental and atropine. Miorelaksiruyuschee action anadroll reinforced with antibiotics such as aminoglycosides or polypeptides, amphotericin B, cyclopropane, propanidid, quinidine, and thiotepa. parasympathomimetics, including cholinesterase inhibitors. aymalinu, beta-blockers, calcium channel blockers, cyclophosphamide, tiofosfamidom, oxytocin, cimetidine, metoclopramide, phenothiazines. lithium preparations and oral contraceptives. Avoid concurrent use of inhaled anesthetics, as it increases the risk of malignant hyperthermia and enhances neuromuscular block associated with listenon ® . suxamethonium chloride enhances the effect of drugs digitalis (risk of onset of arrhythmia).Simultaneous infusion of whole blood or plasma weakens action listenon ® .

Special instructions
have been reported cases of irreversible cardiac arrest after administration of suxamethonium chloride in children and adolescents who had not previously discovered neuromuscular disease. Because of the danger of side effects it is recommended to limit the application of suxamethonium chloride even in apparently healthy children and adolescents, except in cases that require immediate intubation or clearing the airway in an emergency.
Listenon ® , like all muscle relaxants peripherally acting, can only be administered by doctors who have experience with the devices artificial respiration and skills of intratracheal intubation and if ready to work artificial respiration apparatus under positive pressure, as well as devices providing sufficient access of oxygen and removal of carbon dioxide.
For the prevention bradycardia, bronchoconstriction or other muskarinopodobnyh effects before taking listenon ® recommended atropine. how much to inject for weight loss

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